Biomedical and Health Sciences

Large p small n problem is a challenging problem in big data analytics. There are no de facto standard methods available to it. In this study, we propose a tensor decomposition (TD) based unsupervised feature extraction (FE) formalism applied to multiomics datasets, where the number of features is more than 100000 while the number of instances is as small as about 100.
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This dataset contains joint kinematics, kinetics, and EMG activity from an experimental protocol approved by the Institutional Review Board at the University of Texas at Dallas. This data was collected to evaluate the robustness of different parameterization variables during perturbations for application in robotic prosthetic legs. Ten able-bodied subjects self-selected a comfortable speed for walking on level (0 degree), +5 degree, and -5 degree inclines. Subjects walked at the self-selected speed for a minute without perturbations to produce a control dataset of unperturbed kinematics.
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The dataset contains medical signs of the sign language including different modalities of color frames, depth frames, infrared frames, body index frames, mapped color body on depth scale, and 2D/3D skeleton information in color and depth scales and camera space. The language level of the signs is mostly Word and 55 signs are performed by 16 persons two times (55x16x2=1760 performance in total).
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Guinea pig erythrocytes without neuraminidase inhibitor. Guinea pig erythrocytes without neuraminidase inhibitor sequence.
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Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3 and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity.
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This Dataset contains EEG recordings from epileptic rats. The genetic absence epilepsy rats (GAERS) are one of the best-established rodent models for generalized epilepsy. The rats show seizures with characteristic "spike and wave discharge" EEG patterns. Experiments were performed in accordance with the German law on animal protection and were approved by the Animal Care and Ethics Committee of the University of Kiel.
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The accurate prediction of new interactions between drugs is important for avoiding unknown (mild or severe) adverse reactions to drug combinations. The development of effective in silico methods for evaluating drug interactions based on gene expression data requires an understanding of how various drugs alter gene expression. Current computational methods for the prediction of drug-drug interactions (DDIs) utilize data for known DDIs to predict unknown interactions. However, these methods are limited in the absence of known predictive DDIs.
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This paper proposes a novel device for wrist motion rehabilitation. The proposed mechatronic architecture is based on a simple user-friendly design, which includes a mobile platform for hand support, which is operated by a single actuator. A dedicated assist-as-needed control is designed to operate the device for the required movements. The proposed control strategy is also integrated into a gaming software for stimulating the exercising by means of various interactions with patients.
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EEG signals of various subjects in text files are uploaded. It can be useful for various EEG signal processing algorithms- filtering, linear prediction, abnormality detection, PCA, ICA etc.
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Participants were 61 children with ADHD and 60 healthy controls (boys and girls, ages 7-12). The ADHD children were diagnosed by an experienced psychiatrist to DSM-IV criteria, and have taken Ritalin for up to 6 months. None of the children in the control group had a history of psychiatric disorders, epilepsy, or any report of high-risk behaviors.
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