The migration of cancer cells is highly regulated by the biomechanical properties of their local microenvironment. Using 3D scaffolds of simple composition, several aspects of cancer cell mechanosensing (signal transduction, EMC remodeling, traction forces) have been separately analyzed in the context of cell migration. However, a combined study of these factors in 3D scaffolds that more closely resemble the complex microenvironment of the cancer ECM is still missing.
Hyperspectral (HS) imaging presents itself as a non-contact, non-ionizing and non-invasive technique, proven to be suitable for medical diagnosis. However, the volume of information contained in these images makes difficult providing the surgeon with information about the boundaries in real-time. To that end, High-Performance-Computing (HPC) platforms become necessary. This paper presents a comparison between the performances provided by five different HPC platforms while processing a spatial-spectral approach to classify HS images, assessing their main benefits and drawbacks.
Monitoring cell viability and proliferation in real-time provides a more comprehensive picture of the changes cells undergo during their lifecycle than can be achieved using traditional end-point assays. Our lab has developed a CMOS biosensor that monitors cell viability through high-resolution capacitance measurements of cell adhesion quality. The system consists of a 3 × 3 mm2 chip with an array of 16 sensors, on-chip digitization, and serial data output that can be interfaced with inexpensive off-the-shelf components.
Malignant pleural effusions (MPEs) are a challenging public health problem, causing significant morbidity and often being the first presenting sign of cancer. Pleural fluid cytology is the most common method used to differentiate malignant from non-malignant effusions. However, its sensitivity reaches 50-70% and depends on the experience of the cytologist, the tumor load, and the amount of fluid tested. Therefore, diagnostic inaccuracy and a high incidence of false negatives may endanger patients with clinical mistreatment and mismanagement.
In this paper, the effects of input power of microwave antenna (MWAN) on liver cancerous tissue at injection of Magnetic Nanoparticles (MNPs) are investigated. At first for base simulation, we validate our results by a comparison with other literature reports. After that, we used a 1.8-cm hepatocellular carcinoma (HCC) tumor that was treated in experiment during a 3-min ablation by using MWAN operating on 2.45 GHz frequency with 90 W power. In the next step of the simulation, the obtained results were compared with experimental results.
This dataset of breast cancer patients was obtained from the 2017 November update of the SEER Program of the NCI, which provides information on population-based cancer statistics. The dataset involved female patients with infiltrating duct and lobular carcinoma breast cancer (SEER primary cites recode NOS histology codes 8522/3) diagnosed in 2006-2010. Patients with unknown tumor size, examined regional LNs, regional positive LNs, and patients whose survival months were less than 1 month were excluded; thus, 4024 patients were ultimately included.
Computational modelling of metabolic processes has proven to be a useful approach to formulate our knowledge and improve our understanding of core biochemical systems that are crucial to maintain cellular functions. Recently, it has become evident that metabolism is not only responsible for generating the required energy and controlling the abundance of metabolites within a cell, but also has an important role in and influence on cellular fate specification.
Videomicroscopic Semi-Shadow Visualization of LoC-Si (Lab-on-a-Chip_[based_on]_Silicone) test structures from Institute of Molecular Electronics (D. Shevchenko; founder of Scientific and Production Association "Microbiotechniques" Ltd.) and Russian Academy of Sciences (INEPCP RAS; ICP RAS)
We make our dataset publicly avaiable. It consists of 50 H&E stained histopathology annotated images at the nuclei level. This dataset is ideal for those who want an exhaustive annotation of H&E breast cancer patient from a Tripple Negative Breast Cancer cohort.
