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Transfer RNAs (tRNAs) are a family of non-coding ribonucleic acids (RNAs) that are involved in protein translation. Cleavage of tRNA through stress-induced ribonucleases results in the production of short tRNA-derived small RNAs (tsRNAs), such as tRNA-derived fragments (tRFs). Recent studies have identified three tRFs - 5'AlaTGC, 5'GluCTC, and 5'GlyGCC - to be released from neurons and significantly elevated in epilepsy patients. Extracellular 5'tRFs are taken up by neurons and act in paracrine to inhibit protein translation.
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Repeated Route Naturalistic Driving Dataset (R2ND2) is a dual-perspective dataset for driver behavior analysis constituent of vehicular data collected using task-specific CAN decoding sensors using OBD port and external sensors, and (b) gaze-measurements collected using industry-standard multi-camera gaze calibration and collection system. Our experiment is designed to consider the variability associated with driving experience that depends on the time of day and provides valuable insights into the correlation of these additional metrics on driver behavior.
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Accurate prediction of protein-ligand binding affinities (PLAs) is essential for drug discovery, repositioning, and design.
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