Image Processing

The C3I Synthetic Human Dataset provides 48 female and 84 male synthetic 3D humans in fbx format generated from iClone 7 Character creator “Realistic Human 100” toolkit with variations in ethnicity, gender, race, age, and clothing. For each of these, it further provides the full-body model with five different facial expressions – Neutral, Angry, Sad, Happy, and Scared. Along with the body models, it also open-sources a data generation pipeline written in python to bring those models into a 3D Computer Graphics tool called Blender.

This open dataset is subject to CC BY-NC-SA 4.0 License. The dataset is intended for scientific research purposes and it cannot be used for commercial purposes. The authors encourage users to use it for public research and as a testbench for private research. Please note that any promotional/marketing material built upon this dataset should be backed by publicly available description of the work leading to the promotional/marketing claims.

This repository contains code to apply the ESPER method to quasi-continuum models of biomolecules exhibiting multiple degrees of freedom, as described in Seitz et al. (2022, IEEE TCI). As inputs into ESPER, detailed instructions are also provided for generating custom synthetic datasets with increasing complexity to mirror known cryo-EM image attributes.

Cryo-EM dataset of 80S ribosomes from yeast. This dataset has been described in Dashti et al. (2014, PNAS) "Trajectories of the ribosome as a Brownian nanomachine". In that study, a subset of the dataset was used to demonstrate the performance of a machine learning technique (now termed ManifoldEM) using manifold embedding to determine the energy landscape of a molecule. The dataset is re-analyzed in Seitz et al.