The migration of cancer cells is highly regulated by the biomechanical properties of their local microenvironment. Using 3D scaffolds of simple composition, several aspects of cancer cell mechanosensing (signal transduction, EMC remodeling, traction forces) have been separately analyzed in the context of cell migration. However, a combined study of these factors in 3D scaffolds that more closely resemble the complex microenvironment of the cancer ECM is still missing.
These datasets were used to produce the results of the following TMI paper: "3D Quantification of Filopodia in Motile Cancer Cells", Castilla C., et al. (2019). IEEE Transactions on Medical Imaging 38(3):862,872.