neuroscience
Objective. Currently, few non-invasive measures exist for directly measuring spinal sensorimotor networks. Electrospinography (ESG) is one non-invasive method but is primarily used to measure evoked responses or for monitoring the spinal cord during surgery. Our objectives for collecting this dataset were to evaluate the feasibility of ESG to measure spinal sensorimotor networks by determining spatiotemporal and functional connectivity changes during single-joint movements at the spinal and cortical levels.
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Co-cultures are a traditional method for studying the cellular properties of cell to cell interactions among different cell types. How network properties in these multicellular synthetic systems vary from monocultures are of particular interest. Understanding the changes in the functional output of these in vitro spiking neural networks can provide new insights into in vivo systems and how to develop biological system models that better reflect physiological conditions - something of paramount importance to the progress of synthetic biology.
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Advances in optical neuroimaging techniques now allow neural activity to be recorded with cellular resolution in awake and behaving animals. Brain motion in these recordings pose a unique challenge. The location of individual neurons must be tracked in 3D over time to accurately extract single neuron activity traces. Recordings from small invertebrates like C. elegans are especially challenging because they undergo very large brain motion and deformation during animal movement.
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