In early 2019, we developed a manually curated database named lncR2metasta to provide a comprehensive repository for the regulations of long non-coding RNAs (lncRNAs, an important ncRNA type) during various CMEs. We updated this database this year by supplementing other two important ncRNA types, microRNAs (miRNAs) and circular RNAs (circRNAs), for their involvement during various CMEs after a thorough manual curation from published studies.