ncR2Met (lncR2metasta v2.0): an updated database for experimentally supported ncRNAs during various cancer metastatic events

In early 2019, we developed a manually curated database named lncR2metasta to provide a comprehensive repository for the regulations of long non-coding RNAs (lncRNAs, an important ncRNA type) during various CMEs. We updated this database this year by supplementing other two important ncRNA types, microRNAs (miRNAs) and circular RNAs (circRNAs), for their involvement during various CMEs after a thorough manual curation from published studies. As of 2022, ncR2metasta documents 1565 lncRNA-associated, 882 miRNA-associated, and 628 circRNA-associated entries for the ncRNA-CME associations during 50 CMEs across 63 human cancer subtypes. We implemented a concise web interface in ncR2Met for researchers to easily browse, search and download as well as to submit novel ncRNA-CME associations. We anticipated that ncR2Met could be a timely and valuable resource, which will significantly improve our understanding of ncRNA functions in metastasis. It is freely available at http://ncr2met.wchoda.com.