Diffusion and Displacement Encoded MRI Dataset to Estimate In Vivo Cardiomyocyte Strain
Changes in left ventricular (LV) aggregate cardiomyocyte orientation and deformation underlie cardiac function and dysfunction. As such, in vivo aggregate cardiomyocyte "myofiber" strain has mechanistic significance, but currently there exists no established technique to measure in vivo cardiomyocyte strain.
The following dataset contains Dispalcement Encoding with Stimulated Echoes (DENSE) MRI and cardiac Diffusion Tensor Imaging (cDTI) data. The functional data from DENSE MRI along with the microstructural data reconstructed from cDTI can be used to compute strain along the cardiomyocyte axis.
## Supplemental MRI Data for in vivo estimation of cardiomyocyte strain ##
The contents of this dataset includes the necessary DENSE MRI and cDTI data to
compute in vivo cardiomyocyte strain at one mid-ventricular location. The
following README file will break down the contents of this supplemental dataset.
A detailed description of the methods used to compute cardiomyocyte strain from
the attached data can be found in the following work:
> Verzhbinsky, I.A., Perotti, L.E., Moulin K., Cork, T.E., Loecher, M.,
> Ennis, D.B. (2019). Estimating Aggregate Cardiomyocyte Strain Using In Vivo
> Diffusion and Displacement Encoded MRI.
### DENSE folder
#### Dicom subfolder
The DENSE folder contains all DENSE MRI data in the 'Dicom' subfolder. Data is
divided into magnitude, x phase, y phase, and z phase dicoms for 2 DENSE MRI
slices located 4 mm above and below the location of cDTI.
#### Processed subfolder
The 'Processed' subfolder contains the processed Langrangian displacements for
each DENSE MRI slice in a MatLab file format. DENSE MRI displacement data was
processed using the following open-source DENSE processing tool:
### cDTI folder
#### Dicom subfolder
Diffusion weighted dicom data acquired across the entire left ventricle is
located in the Dicom subfolder. The data is organized into 1 b0 image followed
by 12 diffusion weighted images repeated 30 times.
(1 b0 + 12 Diffusion) * 30 averages = 390 total images.
The cDTI slice that is located between the 2 provided DENSE slices is number 6,
with image number 1 beginning at the most apical slice.
### Processed subfoler
The processed subfolder contains a single MatLab file with the diffusion weighed
images and reconstructed diffusion tensors registered to the DENSE MRI data.
'IMaffine' - a cDTI image matrix at slice 6 with the following dimensions:
[yres xres (b0 + 12 diffusion)]
'D' - the registered reconstructed diffusion tensors at slice 6 with the
[yres xres 3 3]
At each cDTI voxel, all reconstructed diffusion tensors are represented as
symmetric 3 by 3 matrices.