Retinal Fundus Multi-disease Image Dataset (RFMiD 2.0) is an auxiliary dataset to our previously published dataset. RFMiD 2.0 is a more challenging dataset to research society to develop the computer-based disease diagnosis system. Diabetic Retinopathy, cataracts, and refractive error in the eye are leading disease which causes permanent vision loss more frequently. Therefore, developing an AI-based model to classify these diseases is useful for ophthalmologists. This dataset consists of 860 images of frequently and rarely observed 51 diseases.