This study investigated possible long-term cardiotoxicity-related left-ventricular (LV) contractile dysfunction in breast cancer patients who had treatment with anti-neoplastic chemotherapy agents (CTA). An automated cardiac contractility analysis tool consisting of quantization-based boundary detection and meshfree Radial Point Interpolation Method-based numerical analysis measured torsion and 3D strains for comparisons to healthy subjects to investigate LV remodeling otherwise not indicated by LV ejection fraction (LVEF).