Synaptic vesicle glycoprotein 2A (SV2A) is the most widely distributed transmembrane glycoprotein present on secretory vesicles in the pre-synaptic terminal of neurons throughout the central nervous system (Bajjalieh et al., 1994).  SV2A can be used as a marker to visualize pre-synaptic density distribution in vivo using positron emission tomography (PET) imaging thanks to the SV2A radioligands available, including [11C]UCB-J (Nabulsi et al., 2016). Given the brain-wide distribution of SV2A, regional analysis of SV2A PET data may be limiting the amount of information that can be obtained.