speckle contrast optical spectroscopy

Speckle contrast optical spectroscopy (SCOS) is an optical technique capable of measuring human cerebral blood flow and brain function non-invasively. Its tomographic extension, speckle contrast optical tomography (SCOT), can provide blood flow variation maps with measurements using overlapping source-detector channel pairs. Linearity is often assumed in most image reconstruction methods, but non-linearity could exist in the relations between measured signals and blood flow variations.