Optimization of Power used in Liver Cancer Microwave Therapy by Injection of Magnetic Nanoparticles (MNPs)

Citation Author(s):
mehran
minbashi
Iran University of Science and Technology
Amirhossein
Ahmadkhan Kordbache
Iran University of Science and Technology
Valery
V. Tuchin
Saratov State University
Submitted by:
mehran minbashi
Last updated:
Fri, 03/01/2019 - 19:35
DOI:
10.21227/ffcz-0z10
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Abstract 

In this paper, the effects of input power of microwave antenna (MWAN) on liver cancerous tissue at injection of Magnetic Nanoparticles (MNPs) are investigated. At first for base simulation, we validate our results by a comparison with other literature reports. After that, we used a 1.8-cm hepatocellular carcinoma (HCC) tumor that was treated in experiment during a 3-min ablation by using MWAN operating on 2.45 GHz frequency with 90 W power. In the next step of the simulation, the obtained results were compared with experimental results. In the last step of MNPs’ injection in the tumor, the effects of various input powers of MWA were studied. Our results show that MNPs can be used as a good heat source and reduce input power for completing hyperthermia. when maghemite γ-Fe2O3 is used as a MNP, the input power would be reduced from 90 W to 35 W. In addition, it is demonstrated that a higher external magnetic field can treat the tumor with a higher radius. The optimized values of the external magnetic field and the input power used in these simulations are 15 mT and 35 W, respectively.

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