circRNA-durg sensitivity data

Citation Author(s):
Hongwei
Xia
Submitted by:
Hongwei xia
Last updated:
Wed, 05/29/2024 - 21:29
DOI:
10.21227/e4bg-ab29
License:
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Abstract 

we searched the circRic database to gather data on the correlations between circRNAs and drug sensitivities, while the GDSC database contains information about drug sensitivities. The initial data set covers 80,076 associations related to 404 circRNAs and 250 drugs. The Wilcoxon test was used to determine the significant circRNA-drug sensitivity correlations. The procedure was contingent upon the false discovery rate (FDR) being less than 0.05. The final dataset contains 4134 significant associations involved 218 drugs and 271 circRNAs.  In addition to the associations between circRNAs and drug sensitivities, we also obtained circRNA host gene sequences and drug structures from the National Center for Biotechnology Information (NCBI) gene database and NCBI's PubChem database, which are then used to derive their similarity matrices, respectively.

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