Histopathology Dataset; Oral Squamous Cell Carcinoma; Diagnosis; Prognosis; Multiple Tasks

We present a dataset of histopathology images from OSCC patients treated at Sun Yat-sen Memorial Hospital (2015–2022). Each case includes two tissue sections (core and boundary), with six images per patient captured at ×200, ×400, and ×1000 magnifications (2592×1944 pixels). Key histopathological features—such as cancer cells, nests, keratin pearls, nuclear atypia, and necrosis—are included. The study was approved by the Ethics Committee with a waiver of informed consent, and patient-level diagnosis and prognosis annotations were obtained from electronic records.