calcium imaging; deep learning; warp correction; image registration; denoising

Calcium imaging visualizes specific activity of neurons through active sensors, which makes it easy to study the neuronal behavior of animals' learning processes and cognition and helps to promote the use of animal models for neuroscience research. However, motion artifacts and background noise can affect calcium imaging, especially when watching awake animals while they are exposed to low-dose laser irradiation. This makes it impossible to fully understand how neural circuits work. As a result, imaging results are often warped and contain significant random noise.