Numerous studies have demonstrated that microbes play a vital role in human health, making the identification of potential microbe-drug associations critical for drug discovery and clinical treatment. In this manuscript, we proposed a novel prediction model named GTDEKAN by integrating an aware Transformer network with a Dual Cross-Attention (DCA) module (including a Channel Cross-Attention and a Spatial Cross-Attention) and an Enhanced Kolmogorov-Arnold Network (EKAN) to infer potential microbe-drug associations.