Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3 and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity.

DOI Link: 
10.21227/2wtc-wd25
Links or DOI: 
Breast Invasive Carcinoma
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[1] Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou, "Breast Invasive Carcinoma", IEEE Dataport, 2020. [Online]. Available: http://dx.doi.org/10.21227/2wtc-wd25. Accessed: Mar. 13, 2025.
@data{2wtc-wd25-20,
doi = {10.21227/2wtc-wd25},
url = {http://dx.doi.org/10.21227/2wtc-wd25},
author = {Giovanni Ciriello; Michael L Gatza; Andrew H Beck; Matthew D Wilkerson; Suhn K Rhie ; Alessandro Pastore; Hailei Zhang; Michael McLellan; Christina Yau; Cyriac Kandoth; Reanne Bowlby; Hui Shen; Sikander Hayat; Robert Fieldhouse; Susan C Lester; Gary M K Tse; Rachel E Factor; Laura C Collins ; Kimberly H Allison ; Yunn-Yi Chen; Kristin Jensen ; Nicole B Johnson; Steffi Oesterreich ; Gordon B Mills ; Andrew D Cherniack; Gordon Robertson; Christopher Benz; Chris Sander ; Peter W Laird; Katherine A Hoadley; Tari A King ; TCGA Research Network; Charles M Perou },
publisher = {IEEE Dataport},
title = {Breast Invasive Carcinoma},
year = {2020} }
TY - DATA
T1 - Breast Invasive Carcinoma
AU - Giovanni Ciriello; Michael L Gatza; Andrew H Beck; Matthew D Wilkerson; Suhn K Rhie ; Alessandro Pastore; Hailei Zhang; Michael McLellan; Christina Yau; Cyriac Kandoth; Reanne Bowlby; Hui Shen; Sikander Hayat; Robert Fieldhouse; Susan C Lester; Gary M K Tse; Rachel E Factor; Laura C Collins ; Kimberly H Allison ; Yunn-Yi Chen; Kristin Jensen ; Nicole B Johnson; Steffi Oesterreich ; Gordon B Mills ; Andrew D Cherniack; Gordon Robertson; Christopher Benz; Chris Sander ; Peter W Laird; Katherine A Hoadley; Tari A King ; TCGA Research Network; Charles M Perou
PY - 2020
PB - IEEE Dataport
UR - 10.21227/2wtc-wd25
ER -
Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou. (2020). Breast Invasive Carcinoma. IEEE Dataport. http://dx.doi.org/10.21227/2wtc-wd25
Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou, 2020. Breast Invasive Carcinoma. Available at: http://dx.doi.org/10.21227/2wtc-wd25.
Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou. (2020). "Breast Invasive Carcinoma." Web.
1. Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou. Breast Invasive Carcinoma [Internet]. IEEE Dataport; 2020. Available from : http://dx.doi.org/10.21227/2wtc-wd25
Giovanni Ciriello, Michael L Gatza, Andrew H Beck, Matthew D Wilkerson, Suhn K Rhie , Alessandro Pastore, Hailei Zhang, Michael McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert Fieldhouse, Susan C Lester, Gary M K Tse, Rachel E Factor, Laura C Collins , Kimberly H Allison , Yunn-Yi Chen, Kristin Jensen , Nicole B Johnson, Steffi Oesterreich , Gordon B Mills , Andrew D Cherniack, Gordon Robertson, Christopher Benz, Chris Sander , Peter W Laird, Katherine A Hoadley, Tari A King , TCGA Research Network, Charles M Perou. "Breast Invasive Carcinoma." doi: 10.21227/2wtc-wd25