Deep learning has revolutionized the field of robotics. To deal with the lack of annotated training samples for learning deep models in robotics, Sim-to-Real transfer has been invented and widely used. However, such deep models trained in simulation environment typically do not transfer very well to the real world due to the challenging problem of “reality gap”. In response, this letter presents a conceptually new Digital Twin (DT)-CycleGAN framework by integrating the advantages of both DT methodology and the CycleGAN model so that the reality gap can be effectively bridged.